No, you can not use a 2-handed weapon to attack when grappling*
Can you grapple while dual wielding?
Yes, you can grapple while holding a two-handed weapon, but no, you can’t attack with it while grappling.
Is grapple a weapon attack?
Grappling is a special attack, but uses strength and skill, not a weapon; PHB 195.
Does Grappling require free hand?
Whenever you make a melee attack, you can choose to try and grapple a dude instead. (You need at least one free hand to do this.)
Is a grapple a melee attack?
An attack involves an attack roll or doing something that the rules call an attack, like grappling or shoving. So, grappling and shoving are are defined as attacks in the rules and designer clarification has verified that (many times in fact). Thus, they qualify as melee attacks for this part of the mobile feat.
How many weapons can you use while grappling?
Attack Your Opponent: You can make an attack with an unarmed strike, natural weapon, or light weapon against another character you are grappling. You take a –4 penalty on such attacks. You can’t attack with two weapons while grappling, even if both are light weapons.
Can you attack the target of a grapple?
Yes. We could dig into the grapple rules (PHB p.195) to show it’s so, but I think there’s an easier place to see it: the Grappler feat (PHB p.167). You have advantage on attack rolls against a creature you are grappling. Clearly, then, one can attack the target of a grapple.
Can You grapple multiple opponents in RuneScape?
When you are grappling with multiple opponents, you choose one opponent to make an opposed check against. The exception is an attempt to escape from the grapple; to successfully escape, your grapple check must beat the check results of each opponent. That doesn’t answer my question, in fact I read that first before asking.
How many opponents can you grapple in one round?
Up to four combatants can grapple a single opponent in a given round. Creatures that are one or more size categories smaller than you count for half, creatures that are one size category larger than you count double, and creatures two or more size categories larger count quadruple.